Abstract Title:

Evaluation of the effect of photodynamic therapy on chemotherapy induced oral mucositis Photodynamic therapy on oral mucositis.

Abstract Source:

Photodiagnosis Photodyn Ther. 2020 Jan 7:101653. Epub 2020 Jan 7. PMID: 31923632

Abstract Author(s):

Fatemeh Lavaee, Ali Amanati, Mani Ramzi, Setareh Naseri, Hajar Shakiba Sefat

Article Affiliation:

Fatemeh Lavaee


BACKGROUND: In this study the effect of photodynamic therapy on chemotherapy induced mucositis was evaluated.

METHODS: This randomized single blind clinical pilot evaluation evaluated the effect of PDT with methylene blue on 15 patients with chemotherapy induced bilateral oral mucositis. They were divided into 2 groups (control side and intervention side). Methylene blue was applied on the lesions of both sides, after 10 minutes the lesion of intervention side was irradiated by a 660 nm diode laser InGaAlP(Azor-2 K) for 10 minutes (power: 25 mW, dose:19.23 J/CM2, probe diameter: 0.78 cm2) for three sessions (day1,[3,5] and followed on day 12. In control side only sham laser was used. Data were analyzedby Wilcoxon and Mann-Whitney test using SPSS version 22.

RESULTS: Comparing the WCCNR and NCI difference in different sessions between intervention and control group, represented significant improvement in oral mucositis in photodynamic therapy group for sessions 1-0, 2-0, 3-0 (P.value<0.05).

CONCLUSION: Photodynamic therapy can improve chemotherapy induced oral mucositis.

Study Type : Human Study

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