Abstract Title:

Trends of inflammatory markers and cytokines after one month of phototherapy in patients with rheumatoid arthritis.

Abstract Source:

Acta Med Acad. 2015 Nov ;44(2):102-8. PMID: 26702905

Abstract Author(s):

José Meneses Calderón, Irma González Sánchez, Guillermo Aburto Huacuz, Arely Sarai Alonso Barreto, María Del Carmen Colín Ferreyra, Hugo Mendieta Zerón

Article Affiliation:

José Meneses Calderón


OBJECTIVE: to evaluate changes in the expression of tumor necrosis factor-α in patients with rheumatoid arthritis submitted to phototherapy.

MATERIALS AND METHODS: This was an open label study, enrolling ten patients. The phototherapy scheme within a range of 425 to 650 nm, 11.33 Joules/cm2, 30 cm above the chest was as follows: a) 45-min daily sessions from Monday to Friday for 2 to 3 months; b) three, 45- min weekly sessions for 1 to 2 months; c) twice weekly 45-min sessions for 1 to 2 months, and d) one weekly session for 1 to 2 months until completion. Erythrocyte sedimentation rate, C-reactive protein and rheumatoid factor were measured in peripheral blood and tumor necrosis factor-α, interleukin-1β, and interleukin-10 in leukocytes by quantitative real-time Reverse transcriptase-Polymerase chain reaction. In all the patients the next indexes: Karnofsky scale, Rheumatoid Arthritis-specific quality of life instrument, Steinbrocker Functional Capacity Rating and the Visual Analog Scale were evaluated.

RESULTS: Erythrocyte sedimentation rate, C-reactive protein, and rheumatoid factor declined notoriously after the indicated sessions. In gene expression, there was a tendency in tumor necrosis factor-α to decrease after 1 month, from 24.5±11.4 to 18±9.2 relative units, without reaching a significant statistical difference. The four tested indexes showed improvement.

CONCLUSION: Phototherapy appears to be a plausible complementary option to reduce the inflammatory component in rheumatoid arthritis.

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