Abstract Title:

Phthalide dimers from Angelica sinensis and their COX-2 inhibition activity.

Abstract Source:

Fitoterapia. 2018 Sep ;129:102-107. Epub 2018 Jun 21. PMID: 29935258

Abstract Author(s):

Jie-Li Lv, Lai-Bin Zhang, Li-Min Guo

Article Affiliation:

Jie-Li Lv


Four new dimeric phthalides, angesinenolides C-F (1-4), along with three known ones, were isolated from the roots of Angelica sinensis. Their structures were determined by means of HRMS and NMR experiments. The structures of compounds 1 and 3 were confirmed using X-ray crystallographic data. All isolated compounds were tested for activities on the inhibition of COX-2 enzyme in vitro. Compounds 1-6 exhibited inhibitory activity against COX-2 with ICvalues ranging from 29.32 ± 0.07 to 137.91 ± 0.24 μM.

Study Type : In Vitro Study

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