Article Publish Status: FREE
Abstract Title:

Physical Exercise and Its Protective Effects on Diabetic Cardiomyopathy: What Is the Evidence?

Abstract Source:

Front Endocrinol (Lausanne). 2018 ;9:729. Epub 2018 Dec 3. PMID: 30559720

Abstract Author(s):

Jia Zheng, Jing Cheng, Sheng Zheng, Ling Zhang, Xiaohui Guo, Junqing Zhang, Xinhua Xiao

Article Affiliation:

Jia Zheng


As one of the most serious complications of diabetes, diabetic cardiomyopathy (DCM) imposes a huge burden on individuals and society, and represents a major public health problem. It has long been recognized that physical exercise has important health benefits for patients with type 2 diabetes, and regular physical exercise can delay or prevent the complications of diabetes. Current studies show that physical exercise has been regarded as an importantly non-pharmacological treatment for diabetes and DCM, with high efficacy and low adverse events. It can inhibit the pathological processes of myocardial apoptosis, myocardial fibrosis, and myocardial microvascular diseases through improving myocardial metabolism, enhancing the regulation of Ca, and protecting the function of mitochondria. Eventually, it can alleviate the occurrence and development of diabetic complications. Describing the mechanisms of physical exercise on DCM may provide a new theory for alleviating, or even reversing the development of DCM, and prevent it from developing to heart failure.

Study Type : Review

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Sayer Ji
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