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Abstract Title:

Physicochemical characterization and the hypoglycemia effects of polysaccharide isolated fromSims peel.

Abstract Source:

Food Funct. 2021 Apr 20. Epub 2021 Apr 20. PMID: 33876796

Abstract Author(s):

Yuan Guan, Hefei Sun, Huiying Chen, Peijun Li, Yang Shan, Xia Li

Article Affiliation:

Yuan Guan

Abstract:

One polysaccharide, designated as WPEP-A, was isolated from Passiflora edulis Sims peel and its hypoglycemic effects on diabetic db/db mice were evaluated. Physicochemical characterization showed that WPEP-A was composed of galactose, glucose, xylose, rhamnose, galacturonic acid and glucuronic acid with a molecular weight of 9.51× 104 Da. We observed an inhibition in weight gain and blood glucose levels. Glucose tolerance and insulin tolerance improved after the administration of WPEP-A. In addition, our data showed increased antioxidant enzyme activities. Furthermore, the levels of serum insulin and triglyceride decreasedwith the recovery of liver damage. Meanwhile, positive changes in short chain fatty acid content were observed, and the mRNA levels of glucagon-like peptide 1 receptor, glucagon and prohormone convertase 3 were up-regulated in the intestinal tract. In summary, our results showed that WPEP-A had hypoglycemic activity and improved intestinal function in diabetic mice, which may contribute to the attenuation of the hypoglycemia effects.

Study Type : Animal Study

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