Abstract Title:

Phytochemical analysis and antioxidant activity of the seed of Telfairia occidentalis Hook (Cucurbitaceae).

Abstract Source:

Nat Prod Res. 2018 Feb ;32(4):444-447. Epub 2017 Mar 31. PMID: 28361553

Abstract Author(s):

Olorunfemi A Eseyin, Akaninyene Daniel, Thomas S Paul, Emmanuel Attih, Essien Emmanuel, Johnson Ekarika, Abdul Sattar Munavvar Zubaid, Ahmad Ashfaq, Sheryar Afzal, Akpan Ukeme

Article Affiliation:

Olorunfemi A Eseyin


The 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical, nitric oxide, reducing power, hydrogen peroxide scavenging, and total antioxidant activities of the methanol extract, n-hexane, dichloromethane, ethyl acetate, butanol and aqueous fractions of the seed of Telfairia occidentalis were evaluated. Total phenolic content was determined using the Folin-Ciocalteu method. The dichloromethane fraction exhibited the highest DPPH radical scavenging, reducing power and total antioxidant activities. Two pure compounds which were identified by FTIR, H-and 2D NMR and Mass spectroscopy as 9-octadecenoic acid (TOS B) and 10-hydroxyoctadecanoic acid (TOS C) and four oily isolates, TOS A, TOS D, TOS E and TOS F were obtained from the dichloromethane fraction. TOS E had the highest DPPH radical scavening activity comparable to that of ascorbic acid. GC-MS analysis revealed the major compounds in TOS E as 4-(2,2-Dimethyl-6-methylene cyclohexylidene)-2-butanol; 3-(3-hydroxybutyl)-2,4,4-trimethyl-2-cyclohexene-1-one and 1,2-Benzenedicarboxylic acid disooctyl ester. Thus, the seed of T. occidentalis can be consumed for its antioxidant property.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856)

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