n/a
Article Publish Status: FREE
Abstract Title:

Phytochemical Screening ofL. as a Potential Anticholinesterase and Antioxidant-Medicinal Plant for Cognitive Decline Disorders.

Abstract Source:

Plants (Basel). 2022 Feb 14 ;11(4). Epub 2022 Feb 14. PMID: 35214846

Abstract Author(s):

Majid Rasool Kamli, Abeer Abdullah M Sharaf, Jamal S M Sabir, Irfan A Rather

Article Affiliation:

Majid Rasool Kamli

Abstract:

The inhibition of acetylcholinesterase (AChE) by cholinergic agents has been promoted as a potent strategy for treating and managing cognitive decline disorders. A wide range of natural products has long been used as potential sources or formulations of cholinergic inhibitors. Therefore, this study aimed to evaluate differentL. () extracts for their AChE inhibitory activity using galanthamine as a standard AChE inhibitor. In this study, the ethyl-acetate extract (at a concentration of 250µg/mL) exhibited the greatest inhibitory effect against AChE with significant inhibition of 75%, comparable to the inhibitor galanthamine with an inhibition of 88%. Kinetic analysis revealed that the extracts could induce a mixed type of inhibition, as observed in the case of galanthamine, with thehighest increasedand decreasedvalues in the ethyl acetate extract. The antioxidant potential of the three extracts tested was found to be in the order of ethyl-acetate>ethanol>aqueous, with ICvalues of 272µg/mL, 387 µg/mL, and 534 µg/mL, respectively. Ethyl-acetate was found to have the highest total phenolic content in all extracts. Further, in silico study showed structural binding characterization of rosmarinic acid and carnosic acid with human AChE enzyme. Rosmarinic acid showed strong bindingand formed two hydrogen-bonding interactions with Ser-293 and Arg-296. In light of this, the ethyl-acetate extract of the plant may provide some novel potential pharmacological leads for treating and managing cognitive disorders such as Alzheimer's.

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.