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Abstract Title:

Phytochemicals of Pogostemon Cablin (Blanco) Benth. aqueous extract: Their xanthine oxidase inhibitory activities.

Abstract Source:

Biomed Pharmacother. 2017 May ;89:544-548. Epub 2017 Mar 1. PMID: 28259096

Abstract Author(s):

Fang Liu, Chao Deng, Wei Cao, Guangyao Zeng, Xu Deng, Yingjun Zhou

Article Affiliation:

Fang Liu

Abstract:

Bioassay-guided fractionation of the aerial part of P. cablin revealed that fraction A3 of the water extract exhibited significant xanthine oxidase inhibitory activities (IC=85.42±1.71μg/mL), which further led to the isolation of ten more bioactive compounds, including two new compounds (1 and 2). The structures of compounds 1 and 2 were elucidated by extensive spectral analysis. It is revealed that flavonoids and phenolic compounds were found to be responsible for the xanthine oxidase inhibitory activities of P. cablin. Especially, rosmarinic acid was found to be with potent XO inhibitory activity (IC=8.53±0.91μg/mL).

Study Type : In Vitro Study

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