Article Publish Status: FREE
Abstract Title:

Anti-tumor effect ofα-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest.

Abstract Source:

J Pharmacol Sci. 2015 Mar ;127(3):332-8. Epub 2015 Feb 7. PMID: 25837931

Abstract Author(s):

Weiqiang Chen, Ying Liu, Ming Li, Jianwen Mao, Lirong Zhang, Rongbo Huang, Xiaobao Jin, Lianbao Ye

Article Affiliation:

Weiqiang Chen


Pine needle oil from crude extract of pine needles has been used as an anti-cancer agent in Traditional Chinese Medicine. Theα-pinene is a natural compound isolated from pine needle oil which has been shown anti-cancer activity. In previous study, we found that pine needle oil exhibited significant inhibitory effect on hepatoma carcinoma BEL-7402 cells. In this study, we investigate the inhibition of α-pinene on hepatoma carcinoma BEL-7402 cells in vitro and in vivo and further explore the mechanism. The results show that liver cancer cell growth was inhibited obviously with inhibitory rate of 79.3% in vitro and 69.1% in vivo, Chk1 and Chk2 levels were upregulated, CyclinB, CDC25 and CDK1 levels were downregulated.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022, Journal Articles copyright of original owners, MeSH copyright NLM.