Abstract Title:

On pineal calcification and its relation to subjective sleep perception: a hypothesis-driven pilot study.

Abstract Source:

Psychiatry Res. 1998 Jun 30;82(3):187-91. PMID: 9754443

Abstract Author(s):

D Kunz, F Bes, P Schlattmann, W M Herrmann

Article Affiliation:

Department of Psychiatry, Interdisciplinary Sleep Clinic, Freie Universit√§t Berlin, Germany. [email protected]


We classified the degree of pineal calcification (DOC) into seven groups using cranial Computer Tomography (cCT) and then correlated pineal DOC to chronic subjective sleep-related disturbances as measured by a sleep questionnaire in 36 patients. Analysed by logistic regression models, age and sex were not, but higher pineal DOC was significantly associated with the presence of daytime tiredness (OR = 4.15, 95% CI: 1.63, 10.54) and sleep disturbance (OR = 1.74, 95% CI: 1.10, 2.74). This study provides initial confirmation of the hypothesis that the increasing degree of pineal calcification (DOC) might indicate a decrease of melatonin production, which consecutively might lead to a disturbed circadian rhythmicity in the sleep-wake cycle, with the principal symptom being daytime tiredness.

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