Article Publish Status: FREE
Abstract Title:

Piperine Impedes Biofilm Formation and Hyphal Morphogenesis of.

Abstract Source:

Front Microbiol. 2020 ;11:756. Epub 2020 May 13. PMID: 32477284

Abstract Author(s):

Arumugam Priya, Shunmugiah Karutha Pandian

Article Affiliation:

Arumugam Priya


is the primary etiological agent associated with the pathogenesis of candidiasis. Unrestricted growth ofin the oral cavity may lead to oral candidiasis, which can progress to systemic infections in worst scenarios. Biofilm ofencompasses yeast and hyphal forms, where hyphal formation and yeast to hyphal morphological transitions are contemplated as the key virulence elements. Current clinical repercussions necessitate the identification of therapeutic agent that can limit the biofilm formation and escalating the susceptibility ofto immune system and conventional antifungals. In the present study, a plant-derived alkaloid molecule, piperine, was investigated for the antibiofilm and antihyphal activities againstPiperine demonstrated a concentration-dependent antibiofilm activity without exerting negative impact on growth and metabolic activity. Inhibition in the hyphal development was witnessed through confocal laser-scanning microscopy and scanning electron microscopy. Interestingly, piperine displayed a tremendous potential to inhibit the virulence-associated colony morphologies, such as filamentation and wrinkling. Furthermore, piperine regulated morphological transitions between yeast and hyphal forms by inhibiting hyphal extension and swapping hyphal phase to yeast forms yet under filamentation-inducing circumstances. Remarkably, piperine-challengedexhibited low potential for spontaneous antibiofilm resistance development. In addition, piperine effectively reducedcolonization and prolonged survival of-infected, thereby expounding the distinct antivirulent potential. Transcriptomic analysis revealed piperine significantly downregulating the expression of several biofilm related and hyphal-specific genes (,,,, etc.). Furthermore, no acute toxicity was observed in the HBECs and nematodes exposed to piperine. Altogether, results from this study reveals the potential of piperine to inhibit biofilm and hyphal morphogenesis, and itsefficacy and innocuous nature to HBECs suggests that piperine may be considered as a potential candidate for the treatment of biofilm-associatedinfection, especially for oral candidiasis.

Study Type : In Vitro Study

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