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Article Publish Status: FREE
Abstract Title:

The Pivotal Role of Oleuropein in the Anti-Diabetic Action of the Mediterranean Diet: A Concise Review.

Abstract Source:

Pharmaceutics. 2021 Dec 25 ;14(1). Epub 2021 Dec 25. PMID: 35056936

Abstract Author(s):

Andrea Da Porto, Gabriele Brosolo, Viviana Casarsa, Luca Bulfone, Laura Scandolin, Cristiana Catena, Leonardo A Sechi

Article Affiliation:

Andrea Da Porto

Abstract:

Type 2 diabetes currently accounts for more than 90% of all diabetic patients. Lifestyle interventions and notably dietary modifications are one of the mainstays for the prevention and treatment of type 2 diabetes. In this context, the Mediterranean diet with its elevated content of phytonutrients has been demonstrated to effectively improve glucose homeostasis. Oleuropein is the most abundant polyphenolic compound contained in extra-virgin olive oil and might account for some of the anti-diabetic actions of the Mediterranean diet. With the aim to provide an overview of the possible contributions of oleuropein to glucose metabolism, we conducted a PubMed/Medline search in order to provide an update to the available evidence regarding this interesting compound. This narrative review summarizes the data that was obtained in in vitro and animal studies and the results of clinical investigations. Preclinical studies indicate that oleuropein improves glucose transport, increases insulin sensitivity, and facilitates insulin secretion by pancreaticβ-cells, thereby supporting the hypothesis of the possible benefits of the control of hyperglycemia. However, on the clinical side, the available evidence is still preliminary and requires more extensive investigations. Thus, many questions remain unanswered in regards to the potential benefits ofoleuropein in diabetes prevention and treatment. These questions should be addressed in appropriately designed studies in the future.

Study Type : Review

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