Abstract Title:

PMand water-soluble components induce airway fibrosis through TGF-β1/Smad3 signaling pathway in asthmatic rats.

Abstract Source:

Mol Immunol. 2021 Jun 24 ;137:1-10. Epub 2021 Jun 24. PMID: 34175710

Abstract Author(s):

Hongyan Wu, Dan Wang, Hao Shi, Nannan Liu, Caihong Wang, Jiayu Tian, Xin Wang, Zhihong Zhang

Article Affiliation:

Hongyan Wu


Epidemiological studies have suggested that fine particulate matter (PM) and asthma have been independently associated with pulmonary fibrosis but rarely studied together. Furthermore, it is unknown whether airway fibrosis in asthma is more attributable to water-soluble ions of PM. Our current study was to explore the potential mechanism of PMand water-soluble components on airway fibrosis in ovalbumin (OVA)-sensitized asthmatic rats. Rats were intratracheally instilled with PMand water-soluble components every 3 days for 4 times or 8 times. Histopathological examination demonstrated that lung inflammatory and airway fibrosis were induced after PMand water-soluble components exposure. Meanwhile, PM, in particular water-soluble extracts, increased expression of collagen 1 (COL-1), connective tissue growth factor (CTGF), interleukin-6 (IL-6), transforming growth factor-β1 (TGF-β1), Smad family member 3 (Smad3), and p-Smad3, whereas decreased secretion of heme oxygenase-1 (HO-1). However, pretreating asthmatic rats with SB432542, the inhibitor of TGF-β1, and SIS3 HCl, the antagonist of Smad3, both reversed the activation of airway fibrosis induced by water-soluble extracts. Therefore, TGF-β1/Smad3 signaling pathway may be responsible for the pathological process of airway fibrosis in asthmatic rats following PMand water-soluble components exposure.

Study Type : Animal Study

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