Article Publish Status: FREE
Abstract Title:

Polyphenol Extract from Evening Primrose () Inhibits Invasion Properties of Human Malignant Pleural Mesothelioma Cells.

Abstract Source:

Biomolecules. 2020 Nov 19 ;10(11). Epub 2020 Nov 19. PMID: 33228230

Abstract Author(s):

Malgorzata Chmielewska-Kassassir, Katarzyna Sobierajska, Wojciech M Ciszewski, Malgorzata Bukowiecka-Matusiak, Dorota Szczesna, Izabela Burzynska-Pedziwiatr, Wieslaw Wiczkowski, Waldemar Wagner, Lucyna A Wozniak

Article Affiliation:

Malgorzata Chmielewska-Kassassir


Extracts from the defatted evening primrose (Hudziok) seeds are the source of a range of stable polyphenolic compounds, including ellagic acid, gallic acid, and catechin. Our studies evaluate, for the first time, the influence of evening primrose isopropanol extract (EPE) on malignant pleural mesothelioma (MPM) cells. MPM is rarely diagnosed, its high aggressiveness and frequently noted chemoresistance limit its treatment schemes and it is characterized by low prognostic features. Here, we demonstrate that EPE inhibited MPM growth in a dose-dependent manner in cells with increased invasion properties. Moreover, EPE treatment resulted in cell cycle arrest in the G2/M phase and increased apoptosis in invasive MPM cell lines. Additionally, EPE strongly limited invasion and MMP-7 secretion in MPM cancer cells. Our original data provide evidence about the potential anti-invasive effects of EPE in MPM therapy treatment.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.