Abstract Title:

Polysaccharide from Echinacea purpurea reduce the oxidant stress in vitro and in vivo.

Abstract Source:

Int J Biol Macromol. 2020 Jan 14. Epub 2020 Jan 14. PMID: 31953178

Abstract Author(s):

Ranran Hou, Tianli Xu, Qiu Li, Fengfang Yang, Chunyuan Wang, Tingting Huang, Zhihui Hao

Article Affiliation:

Ranran Hou


Echinacea purpurea polysaccharides (EPPS) were extracted through water extract and alcohol precipitate method. Three polysaccharides were purified by DEAE cellulose, named EPPS-1, EPPS-2 and EPPS-3. The antioxidant activities in three polysaccharides were screened by free radical scavenging test and EPPS-3 possessed the best antioxidant function. Then the antioxidant activities of EPPS-3 were further explored in oxidative damage model in vitro and in vivo for the first time. The results showed that the antioxidases and the metabolism content were significantly improved in EPPS-3 group. EPPS-3 could protect hepatic tissue from the injury of CClcompared with the oxidative damage model. The mechanism research demonstrated that EPPS-3 restrained cell apoptosis and promoted Nrf2 cell signal pathway to play an antioxidant impact. Therefore, EPPS-3 an ingredient could be served as amazing gift for food industry and feed additive.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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