Polysaccharides obtained from Cordyceps militaris alleviate hyperglycemia. - GreenMedInfo Summary
Polysaccharides Obtained fromAlleviate Hyperglycemia by Regulating Gut Microbiota in Mice Fed a High-Fat/Sucrose Diet.
Foods. 2021 Aug 12 ;10(8). Epub 2021 Aug 12. PMID: 34441649
Bao-Hong Lee
Polysaccharides isolated from fungusdisplay multi-biofunctions, such as immunostimulation, down-regulation of hyperlipidemia, and anti-cancer function. The occurrence of obesity and metabolic syndrome is related to the imbalance of gut microbiota. In this study, the effects ofand its fractions on modifying metabolic syndrome in mice were evaluated. Mice were fed a high-fat/high-sucrose diet (HFSD) for 14 weeks to induce body weight increase and hyperlipidemia symptoms in mice, and then the mice were simultaneously given a HFSD andsamples for a further 8 weeks. The results indicated that the fruit body, polysaccharides, and cordycepin obtained fromhad different efficacies on regulating metabolic syndrome and gut microbiota in HFSD-treated mice. Polysaccharides derived fromdecreased the levels of blood sugar and serum lipids in mice fed HFSD. In addition,-polysaccharide treatment obviously improved intestinal dysbiosis through promoting the population of next generation probioticin the gut of mice fed HFSD. In conclusion, polysaccharides derived fromhave the potential to act as dietary supplements and health food products for modifying the gut microbiota to improve the metabolic syndrome.