Abstract Title:

Polysorbate-80-coated, polymeric curcumin nanoparticles for in vivo anti-depressant activity across BBB and envisaged biomolecular mechanism of action through a proposed pharmacophore model.

Abstract Source:

J Microencapsul. 2016 Nov ;33(7):646-655. Epub 2016 Oct 14. PMID: 27682805

Abstract Author(s):

Mohammad Yusuf, Maria Khan, Riaz A Khan, Ibrahim Abdullah Maghrabi, Bahar Ahmed

Article Affiliation:

Mohammad Yusuf


Depression is a modern world epidemic. Its main causative factor is oxidative stress, as reported in study subjects. Natural products are yet to show significant therapeutic effects in comparison with synthetic drugs. Current study deals with the preparation of brain-targeted polysorbate-80-coated curcumin PLGA nanoparticles (PS-80-CUR-NP), and their characterisation via Spectral and optical methods. PS-80-CUR-NP were evaluated against the oxidative stress-mediated depressant (OSMD) activity via Force despair, Tail suspension tests and stress biomarker assay (SOD and catalase activity). A significant reduction in immobility (p < 0.01) in force despair and tail suspension test and a significant increase (p < 0.001 and p < 0.01) in SOD and catalase activity was found and compared with stress control, which confirmed the OSMD activity of PS-80-CUR-NP at 5 mg equivalent dose. Further, AUC curve of brain homogenates estimated the curcumin concentration of 1.73 ng/g Cat T3 h via HPLC technique.

Study Type : Animal Study
Additional Links
Problem Substances : Polysorbate 80 : CK(1) : AC(1)
Adverse Pharmacological Actions : Blood Brain Barrier Injury : CK(27) : AC(12)

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