Abstract Title:

Comparative, quantitative study of lymphoid and non-lymphoid uptake of 60 nm polystyrene particles.

Abstract Source:

J Drug Target. 1994 ;2(2):151-6. PMID: 8069593

Abstract Author(s):

A M Hillery, P U Jani, A T Florence

Article Affiliation:

Centre for Drug Delivery Research, School of Pharmacy, University of London, UK.


Uptake by gut epithelial tissue of 60 nm polystyrene particles was studied in female Sprague-Dawley rats (180 g, 9 weeks old) after 5 days oral dosing by gavage (14 mg/kg). The gut was divided into lymphoid and non-lymphoid tissue of the small and large intestine, prior to analysis for polystyrene by gel permeation chromatography (GPC). Approximately 10% of the administered dose was recovered from the entire gastrointestinal tract. The total percentage of the administered dose taken up through lymphoid tissue was statistically much greater than through non-lymphoid tissue. It was estimated that 60% of the uptake in the small intestine occurred through the Peyer's patches, even though the patches comprised a small percentage of the total surface area of the small intestinal tissue. A significant amount of the total uptake was shown to occur in the large intestine, particularly in the lymphoid sections of this tissue. These results were confirmed by fluorescence microscopy.

Study Type : Animal Study
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