Pomegranate juice improves the cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: A randomized crossover trial.
J Sci Food Agric. 2019 Oct 23. Epub 2019 Oct 23. PMID: 31646650
Reza Barati Boldaji
BACKGROUND: Pomegranate has antioxidant, cardioprotective, and anti-inflammatory properties. We designed a crossover study, aimed to determine if consumption of pomegranate juice (PJ) improves lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Forty-one hemodialysis patients were randomly assigned to one of the two groups: PJ-treated group receiving 100 ml natural PJ immediately after their dialysis session three times a week and the control group receiving the usual care. After 8 weeks, a 4-week washout period was established and then the role of the groups was exchanged. Lipid profile, blood pressure, and oxidative and inflammatory biomarkers were measured before and after each sequence.
RESULTS: Based on the results of intention-to-treat analysis, triglycerides were decreased in PJ condition and increased in the controls. Conversely, high-density lipoprotein (HDL)-cholesterol was increased in PJ and decreased in the control group. Total and low-density lipoprotein (LDL)-cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition. Total antioxidant capacity increased in PJ condition (P<0.001) and decreased in the controls (P<0.001). Conversely, malondialdehyde and interleukin-6 decreased in PJ (P<0.001) and increased in the control group (P≤0.001). The changes of these biomarkers were significantly different between the two conditions.
CONCLUSION: Eight-week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, HDL cholesterol, oxidative stress, and inflammation in hemodialysis patients. This article is protected by copyright. All rights reserved.