Abstract Title:

Efficacy of porcine placental extract on climacteric symptoms in peri- and postmenopausal women.

Abstract Source:

Climacteric. 2012 Aug 24. Epub 2012 Aug 24. PMID: 22920723

Abstract Author(s):

K Koike, Y Yamamoto, N Suzuki, R Yamazaki, C Yoshikawa, F Takano, K Takuma, K Sugiura, M Inoue

Article Affiliation:

Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa.


Objectives Injections of human placental extract have long been used to treat menopausal symptoms. Recently, porcine placental extract (PPE), an oral supplement, has been developed for this purpose. The aim of this study was to assess whether PPE has an impact on climacteric symptoms in perimenopausal and postmenopausal women. Methods Seventy-six women with climacteric symptoms were enrolled into this open-label, randomized, controlled study. The control group (n = 38) underwent 24 weeks of open treatment with Toki-shakuyaku-san (TJ23), an oral herbal remedy used to alleviate climacteric symptoms. The PPE group (n = 38) received three capsules of PPE/day orally for the initial 12 weeks and six capsules/day for the next 12 weeks. Climacteric symptoms wereevaluated in both groups using the Simplified Menopausal Index (SMI) score, Zung's Self-Rating Depression Scale (ZSDS) and the Spielberger State-Trait Anxiety Inventory (STAI) before commencing treatment, after 12 weeks of treatment and on completion of treatment. Results Treatment with PPE was significantly (p<0.01) more effective in reducing the SMI, ZSDS and STAI measures at 12 and 24 weeks than TJ23 treatment alone. Treatment with PPE was also significantly effective (p< 0.01) in reducing the subscale scores of the SMI for items such as hot flushes, insomnia, irritability, depression, fatigue and joint pain. PPE treatment had no significant adverse effects. Conclusion Oral PPE treatment is another possible option for treating perimenopausal and postmenopausal women with climacteric symptoms.

Study Type : Human Study

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