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Article Publish Status: FREE
Abstract Title:

Positive Effect ofL. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties.

Abstract Source:

Molecules. 2021 Feb 4 ;26(4). Epub 2021 Feb 4. PMID: 33557174

Abstract Author(s):

Martyna Zagórska-Dziok, Tomasz Bujak, Aleksandra Ziemlewska, Zofia Nizioł-Łukaszewska

Article Affiliation:

Martyna Zagórska-Dziok

Abstract:

The skin is an organ that is constantly exposed to many external factors that can affect its structure and function. Due to the presence of different cannabinoid receptors on many types of skin cells, cannabinoids can interact directly with them. Therefore, as part of this work, the impact of two types ofL. herb extracts on keratinocytes and fibroblasts was assessed. The content of biologically active compounds such as phenols, flavonoids, chlorophylls and cannabinoids was evaluated. The antioxidant capacity of prepared extracts using the DPPH radical, HDCFDA probe and measurement of superoxide dismutase activity was also assessed. The cytotoxicity of hemp extracts was determined using the Alamar Blue, Neutral Red and LDH assays. The ability of the extracts to inhibit the activity of matrix metalloproteinases, collagenase and elastase, was assessed. Preparations of model hydrogels were also prepared and their effect on transepidermal water loss and skin hydration was measured. The obtained results indicate that hemp extracts can be a valuable source of biologically active substances that reduce oxidative stress, inhibit skin aging processes and positively affect the viability of skin cells. The analysis also showed that hydrogels based on cannabis extracts have a positive effect on skin hydration.

Study Type : In Vitro Study

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