Article Publish Status: FREE
Abstract Title:

A Positive Relationship between Exposure to Heavy Metals and Development of Chronic Diseases: A Case Study from Chile.

Abstract Source:

Int J Environ Res Public Health. 2021 Feb 3 ;18(4). Epub 2021 Feb 3. PMID: 33546415

Abstract Author(s):

Sandra Cortés, Liliana Zúñiga-Venegas, Floria Pancetti, Alejandra Covarrubias, Muriel Ramírez-Santana, Héctor Adaros, Luis Muñoz

Article Affiliation:

Sandra Cortés


Chile is a mining country, where waste mining is frequently found in the vicinity of inhabited areas. To explore the association between metal exposure and alterations in glucose metabolism, inflammatory status, and oxidative stress in individuals with chronic exposure to metals, a cross-sectional study was performed with 25 volunteers, between 45-65 years old. Inductive coupled plasma mass spectrometry (ICP-MS) was used to measure urinary levels of total arsenic (As) and its metabolites, cooper, nickel, chromium, and lead. Lipid profile, glucose, and insulin were measured in blood, as well as inflammation (interleukin-6, IL-6) and oxidative stress (8-hydroxy-2'deoxyguanosine, 8-OHdG) markers. Increased levels of Low-density lipoprotein, high-density lipoproteins, cholesterol and 8-OHdG, and the index for homeostasis model assessment-insulin resistance (HOMA-IR) were observed in 72%, 60%, and 56% of the volunteers, respectively. Blood-glucose levels were correlated with dimethylarsinic acid (DMA) (R= 0.47,= 0.019), inorganic As (As) (R= 0.40,= 0.012), and Ni (R= 0.56;= 0.044). The models with these compounds explained 72% of the glycemia variability (β= -6.47;β= 6.68;β= 6.87). Ni showed a significantly influence on IL-6 variability (β = 0.85: R= 0.36). Changes in glycemia could be related to exposure to low levels of Asand Ni, representing risk factors for metabolic diseases. Body mass index would confuse the relation between IL-6 and Ni levels, probably due to known chronic inflammation present in obese people.

Study Type : Human Study

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