Post-ECT increases in MRI regional T2 relaxation times in the right and left thalumus are linked to memory impairment in depressed patients. - GreenMedInfo Summary

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Abstract Title:

Post-ECT increases in MRI regional T2 relaxation times and their relationship to cognitive side effects: a pilot study.

Abstract Source:

Psychiatry Res. 1994 Nov ;54(2):177-84. PMID: 7761551

Abstract Author(s):

D J Diehl, M S Keshavan, E Kanal, R D Nebes, T E Nichols, J S Gillen

Article Affiliation:

D J Diehl

Abstract:

This pilot study examined the hypothesis that magnetic resonance imaging T2 relaxation times of specific brain regions increase after electroconvulsive therapy (ECT) and that these increases are related to the cognitive side effects of ECT. Six depressed patients undergoing unilateral ECT were studied. The results demonstrate significant post-ECT T2 increases in the right and left thalamus, and suggest a correlation between regional T2 increase and anterograde memory impairment following ECT. These findings are consistent with a post-ECT increase in brain water content (perhaps secondary to a breakdown of the blood-brain barrier) and suggest that this process may be related to the memory impairment following ECT.

Article Published Date : Oct 31, 1994
Study Type : Human Study
Additional Links
Diseases : Memory Disorders : CK(2447) : AC(643)
Additional Keywords : Blood Brain Barrier : CK(240) : AC(88)
Anti Therapeutic Actions : Electroconvulsive Therapy : CK(1608) : AC(228)

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Key Research Topics

Disease

Memory Disorders

Anti-Therapeutic Action

Electroconvulsive Therapy

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