Abstract Title:

Upper gastrointestinal lesions after potassium chloride supplements: a controlled clinical trial.

Abstract Source:

Lancet. 1982 Nov 13;2(8307):1059-61. PMID: 6127542

Abstract Author(s):

F G McMahon, J R Ryan, K Akdamar, A Ertan


The effects of a new microencapsulated potassium chloride formulation on upper gastrointestinal tract mucosa was compared with that of a popular wax-matrix formulation in 48 healthy volunteers. After a week of KCl, subjects were gastroscoped, the endoscopist being blind to the type of preparation taken. Wax-matrix formulations were associated with a higher incidence of upper gastrointestinal lesions. The lesions were not accompanied by epigastric symptoms. Glycopyrrolate, given to some volunteers to decrease gastric emptying, aggravated the effects of potassium chloride.

Study Type : Human Study

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