Article Publish Status: FREE
Abstract Title:

PotentActivity ofEssential Oil andHydrolate Against Gut Yeast Isolates from Irritable Bowel Syndrome Patients-The Right Mix for Potential Therapeutic Use.

Abstract Source:

Nutrients. 2020 May 7 ;12(5). Epub 2020 May 7. PMID: 32392768

Abstract Author(s):

Maura Di Vito, Maria Grazia Bellardi, Maurizio Sanguinetti, Francesca Mondello, Antonietta Girolamo, Lorenzo Barbanti, Stefania Garzoli, Manuela Sabatino, Rino Ragno, Alberto Vitali, Ivana Palucci, Brunella Posteraro, Antonio Gasbarrini, Gian Maria Prati, Giovanni Aragona, Paola Mattarelli, Francesca Bugli

Article Affiliation:

Maura Di Vito


BACKGROUND: Irritable bowel syndrome (IBS) is a functional disorder without any pathological alteration, in which the alterations of the/s ratio of the gut microbiota, the balance of pro and anti-inflammatory cytokines and the brain-gut-microbiome axis are important for the development and progression of IBS. The aim of the study was to identify natural products, including essential oils or hydrolates, which were contextually harmless for the gut beneficial strains (e.g.spp.) but inhibitory for the pathogenic ones (spp.).

METHODS: The effectiveness of 6 essential oils and 2 hydrolates was evaluated using microbiological tests, carried out on 50 clinical isolates (,andspecies) and 9 probiotic strains (,,and) and immunological and antioxidant assays.

RESULTS: The study led to a mixture based on a 1/100 ratio ofvar.essential oil /cv Italia hydrolate able to contextually reduce, in a concentration-dependent manner, the ability ofspecies to form hyphal filaments and have an interesting immunomodulatory and anti-oxidant action. This mixture can potentially be useful in the IBS treatment promoting the restoration of the intestinal microbial and immunological balance.

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Sayer Ji
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