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Article Publish Status: FREE
Abstract Title:

Potential Anti-Toxoplasmosis Efficiency ofExtracts Loaded on Selenium Nanoparticles.

Abstract Source:

Infect Drug Resist. 2023 ;16:7743-7758. Epub 2023 Dec 20. PMID: 38144223

Abstract Author(s):

Majed H Wakid, Muslimah N Alsulami, Mohamed Farid, Walaa A El Kholy

Article Affiliation:

Majed H Wakid

Abstract:

BACKGROUND: Toxoplasmosis is a parasitic disease caused bythat infects humans and many types of mammals and birds.

OBJECTIVE: To investigate the effect of selenium nanoparticles (SeNPs) and(Pd) extracts loaded on SeNPs as a new agent to combat chronicinfections in murine model as an alternative method to standard Spiramycin drug therapy.

METHODS: A total of 64 female mice were randomly divided into eight groups: GI: Normal control, GII: Positive control, GIII: infected and treated with Spiramycin, GIV: infected and treated with SeNPs, GV: infected and treated with aqueous extract of Pd, GVI: infected and treated with methanolic extract of Pd, GVII: infected and treated with aqueous extract of Pd loaded on SeNPs, GVIII: infected and treated with methanolic extract of Pd loaded on SeNPs. Date palm () fruits were identified and collected from the farms of Saudi Arabia. Preparation and characterization of SeNPs were done. The parasitological, histopathological examinations and biochemical changes were evaluated in all groups.

RESULTS: Parasitological results showed significant differences in GVII in comparison to GII while GVIII showed significant differences in comparison to GII and GIII. The histopathological section of the cerebral cortex showed obvious alterations in the infected compared with untreated control groups. Aqueous and methanolic extracts ofloaded on SeNPs treatment showed improvement that indicated by few perivascular cuffing with few inflammatory cell infiltrations. Few granule cells with mild intracellular vacuolation and edema few deformed neurons with deep pyknotic nuclei. Microglia cells expression of Iba-1 and inflammatory cytokines (IL-4, IL-10 and INF-γ) in serum of all groups was higher in GII and lowest in GVIII followed by GVII.

CONCLUSION: SeNPs andextracts loaded on SeNPs could be a potent agent to combatinfections.

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