n/a
Article Publish Status: FREE
Abstract Title:

Potential of curcumin-loaded cubosomes for topical treatment of cervical cancer.

Abstract Source:

J Colloid Interface Sci. 2022 Aug 15 ;620:419-430. Epub 2022 Apr 8. PMID: 35439693

Abstract Author(s):

Francesca Damiani Victorelli, Livia Salvati Manni, Stefania Biffi, Barbara Bortot, Hilde Harb Buzzá, Viviane Lutz-Bueno, Stephan Handschin, Giovana Calixto, Sergio Murgia, Marlus Chorilli, Raffaele Mezzenga

Article Affiliation:

Francesca Damiani Victorelli

Abstract:

Cervical cancer is one of the most common cancers affecting women worldwide. There are an estimated 570.000 new cases of cervical cancer each year and conventional treatments can cause severe side effects. In this work, we developed a platform for vaginal administration of lipophilic drugs for cervical cancer treatment. We formulated mucoadhesive cubosomes for the delivery of curcumin, a lipophilic drug for cervical cancer treatment, to increase its bioavailability and local absorption. This study tests the use of cubosomes for vaginal drug administration and assesses their potential efficiency using the CAM (chick embryo chorioallantoic membrane) model. SAXS (small-angle X-ray scattering), cryo-TEM (cryo-transmission electron microscopy), and dynamic light scattering (DLS) were employed to characterise the system. With ex vivo permeation and retention studies, we find that the curcumin released from our system is retained in the vaginal mucosa. In vitro cytotoxicity assay and cellular uptake showed an increased cytotoxic effect of curcumin against HeLa cell line when incorporated into the cubosomes. The curcumin-loaded cubosomes also demonstrated an antiangiogenic effect evaluated in vivo by the CAM model.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Cytotoxic : CK(272) : AC(231)

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.