Article Publish Status: FREE
Abstract Title:

Potential ofL. and Hibiscus Acid to Reverse Skin Aging.

Abstract Source:

Molecules. 2022 Sep 17 ;27(18). Epub 2022 Sep 17. PMID: 36144809

Abstract Author(s):

Duanyang Wang, Maki Nagata, Masako Matsumoto, Yhiya Amen, Dongmei Wang, Kuniyoshi Shimizu

Article Affiliation:

Duanyang Wang


L. () has a long history of edible and medicinal uses. In this study, the biological activities of the extracts, chromatographic fractions, and hibiscus acid obtained fromwere evaluated for their potential bioactivities. Their ability to promote extracellular matrix synthesis in skin fibroblasts was evaluated by enzyme-linked immunosorbent assays. Their anti-inflammatory activity was evaluated in a nitric oxide (NO)-Griess inflammatory experiment. Furthermore, hibiscus acid was found to have a strong anti-oxidative stress effect through the establishment of an oxidative stress model induced by hydrogen peroxide. Several assays indicated that hibiscus acid treatment can effectively reduce extracellular adenosine triphosphate (ATP) secretion and carbonyl protein production, as well as maintain a high level of reduced/oxidized glutathione (GSH/GSSG) in skin cells, thus providing a possible mechanism by which hibiscus acid can counter antioxidative stress. The present study is the first to explore the reversing skin aging potential and the contributory component of.

Study Type : In Vitro Study

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