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Article Publish Status: FREE
Abstract Title:

Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review).

Abstract Source:

Int J Mol Med. 2021 04 ;47(4). Epub 2021 Feb 4. PMID: 33537824

Abstract Author(s):

Francisco Javier Turrubiates-Hernández, Gabriela Athziri Sánchez-Zuno, Guillermo González-Estevez, Jorge Hernández-Bello, Gabriela Macedo-Ojeda, José Francisco Muñoz-Valle

Article Affiliation:

Francisco Javier Turrubiates-Hernández

Abstract:

Currently, the world is under a pandemic of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), responsible for coronavirus disease 2019 (COVID‑19). This disease is characterized by a respiratory syndrome that can progress to an acute respiratory distress syndrome. To date, limited effective therapies are available for the prevention or treatment of COVID‑19; therefore, it is necessary to propose novel treatment options with immunomodulatory effects. Vitamin D serves functions in bone health and has been recently reported to exert protective effects against respiratory infections. Observational studies have demonstrated an association between vitamin D deficiency and a poor prognosis of COVID‑19; this is alarming as vitamin D deficiency is a global health problem. In Latin America, the prevalence of vitamin D deficiency is unknown, and currently, this region is in the top 10 according to the number of confirmed COVID‑19 cases. Supplementation withvitamin D may be a useful adjunctive treatment for the prevention of COVID‑19 complications. The present review provides an overview of the current knowledge of the potential immunomodulatory effects of vitamin D in the prevention of COVID‑19 and sets out vitamin D recommendations for the Latin American population.

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