Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L.
Bioorg Med Chem Lett. 2016 Jun 15 ;26(12):2788-94. Epub 2016 Apr 23. PMID: 27156775
Manh Tuan Ha
Detailed phytochemical investigation from the root bark of Morus alba resulted in the isolation of eleven new compounds, including seven 2-arylbenzofuran derivatives (morusalfurans A-G), three flavonoids (morusalnols A-C), and one geranylated stilbene (morusibene A), as well as 22 known compounds. The structures of the identified compounds were elucidated based on a comprehensive analysis of spectroscopic data and Mosher's method. Compounds 2, 3, 6-8, 11, 23, 24, and 29 showed potent inhibition of PL in comparison with the positive control treatment (orlistat, IC50=0.012μM), with IC50 values ranging from 0.09 to 0.92μM.