Abstract Title:

Potential protective effects of polysaccharide extracted from Ulva lactuca against male reprotoxicity induced by thiacloprid.

Abstract Source:

Arch Physiol Biochem. 2017 Dec ;123(5):334-343. Epub 2017 Jul 10. PMID: 28692354

Abstract Author(s):

Intissar Kammoun, Intidhar Bkhairia, Fatma Ben Abdallah, Imen Jaballi, Naourez Ktari, Ons Boudawara, Moncef Nasri, Neji Gharsallah, Ahmed Hakim, Ibtissem Ben Amara

Article Affiliation:

Intissar Kammoun


CONTEXT: Polysaccharides (PSs) from seaweeds have been reported to possess biological activity of potential medicinal values.

OBJECTIVE: The current study was conducted to establish the protective effects of PS extracted from Ulva lactuca against oxidative stress induced by Thiacloprid (THC) in the rat reproductive system.

MATERIALS AND METHODS: Rats were exposed either to THC, THC + PS (100 mg/kg), or THC + PS (200 mg/kg).

RESULTS: Our study showed that THC induced severe disorders in the functional sperm parameters. A decrease in antioxidant activities and their genes expression were observed in the same group, compared to the controls. Our molecular data showing also a severe DNA breakdown in the testis of THC treated group. Moreover, THC treated group showed severe histopathological changes.

CONCLUSIONS: Our results revealed that PS extracted from Ulva lactuca alleviated the THC induced reprotoxicity and reduced oxidative stress damages, DNA breakdown and histological injuries in the testis.

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