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Article Publish Status: FREE
Abstract Title:

Potential therapeutic effects ofandon adenine-induced chronic renal failure in rats and their phytochemical analysis.

Abstract Source:

Drug Des Devel Ther. 2019 ;13:103-117. Epub 2018 Dec 19. PMID: 30587931

Abstract Author(s):

Ling Li, Tong Zhang, Chunru Li, Lu Xie, Ning Li, Tianling Hou, Yuqin Wang, Bing Wang

Article Affiliation:

Ling Li

Abstract:

Background: Natural() has been utilized extensively in traditional Chinese medicine to treat chronic renal diseases, heart palpitations, infantile convulsions, and dizziness. However, given its slow growth and immoderate exploitation,resources have been severely depleted. By contrast,(), as the anamorph stage of, is easy to cultivate, and this kind of cultivatedhas good and controllable quality.

Purpose: This study aimed to compare the therapeutic effects ofandon adenine-induced chronic renal failure (CRF) rats. In accordance with the aforementioned studies, our work subsequently analyzed the intrinsic relationships between the efficacy and pharmacodynamic substances ofandto conclude whether or notcould be used as an alternative toin treating CRF.

Methods: Rats were administered with(1.0 g/kg) or(1.0 g/kg) by gavage for 4 weeks. Furthermore, we applied Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry, liquid chromatography-tandem mass spectrometry, and ultraviolet spectrophotometry to comprehensively detect and analyze the chemical constituent differences from ten batches each ofand.

Results: This study revealed that bothandexerted obvious therapeutic effects on CRF and were more consistent with their chemical compositions.

Conclusion: can be used as an alternative tofor treating CRF to cater to market demands.

Study Type : Animal Study

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