Article Publish Status: FREE
Abstract Title:

Potential therapeutic roles of tanshinone IIA in human bladder cancer cells.

Abstract Source:

Int J Mol Sci. 2014 Sep 4 ;15(9):15622-37. Epub 2014 Sep 4. PMID: 25192287

Abstract Author(s):

Sheng-Chun Chiu, Sung-Ying Huang, Shu-Fang Chang, Shee-Ping Chen, Chi-Cheng Chen, Tien-Huang Lin, Hsin-Ho Liu, Tsung-Hsun Tsai, Shang-Sen Lee, Cheng-Yoong Pang, Teng-Fu Hsieh

Article Affiliation:

Sheng-Chun Chiu


Tanshinone IIA (Tan-IIA), one of the major lipophilic components isolated from the root of Salviae Miltiorrhizae, has been found to exhibit anticancer activity in various cancer cells. We have demonstrated that Tan-IIA induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. Here we explored the anticancer effect of Tan-IIA in human bladder cancer cell lines. Our results showed that Tan-IIA caused bladder cancer cell death in a time- and dose-dependent manner. Tan-IIA induced apoptosis through the mitochondria-dependent pathway in these bladder cancer cells. Tan-IIA also suppressed the migration of bladder cancer cells as revealed by the wound healing and transwell assays. Finally, combination therapy of Tan-IIA with a lower dose of cisplatin successfully killed bladder cancer cells, suggesting that Tan-IIA can serve as a potential anti-cancer agent in bladder cancer.

Study Type : In Vitro Study

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Sayer Ji
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