Potentiation of antibiotic activity byMast. front of strainsand.
Saudi J Biol Sci. 2018 Jan ;25(1):37-43. Epub 2016 Jan 14. PMID: 29379354
Ana Luiza A Siebra
The development of new drugs from plants is an interesting alternative approach to overcoming microbial resistance.shows resistance to diseases and pests and a higher concentration of chemical components that may be useful in the pharmaceutical industry. We investigated the potential antimicrobial and antibiotic-modifying activity of hydroalcoholic extracts of leaves, stems, bark, pulp and seeds of. The extracts were prepared by homogenization of material in 50% ethanol. Minimum inhibitory concentration (MIC) was determined by the broth dilution method, and the bacterial strains tested wereand. Antibiotic-modifying activity was evaluated against the strains03 and08, using a subinhibitory concentration of extract. The antibiotics tested were: amikacin, gentamicin, ampicillin, potassium benzylpenicillin and oxacillin. The extracts did not show antimicrobial activity of clinical relevance, where the MIC was equal to or greater than 1024 μg/mL.showed 13 events, whileshowed only 4 events. Among these events, 14 involved synergistic activity, potentiating the effect of the antibiotics, and only 3 events demonstrated antagonistic activity toward ampicillin. Hydroalcoholic extracts are potential antimicrobial agents when combined with conventional drugs little utilized intreatment.