Article Publish Status: FREE
Abstract Title:

Potentiation of antibiotic activity byMast. front of strainsand.

Abstract Source:

Saudi J Biol Sci. 2018 Jan ;25(1):37-43. Epub 2016 Jan 14. PMID: 29379354

Abstract Author(s):

Ana Luiza A Siebra, Larissa R Oliveira, Anita O B P B Martins, David C Siebra, Rosimeire S Albuquerque, Izabel Cristina Santiago Lemos, Gyllyandeson A Delmondes, Saulo R Tintino, Fernando G Figueredo, Jose Galberto M da Costa, Henrique D M Coutinho, Irwin R A Menezes, Cicero F B Felipe, Marta R Kerntopf

Article Affiliation:

Ana Luiza A Siebra


The development of new drugs from plants is an interesting alternative approach to overcoming microbial resistance.shows resistance to diseases and pests and a higher concentration of chemical components that may be useful in the pharmaceutical industry. We investigated the potential antimicrobial and antibiotic-modifying activity of hydroalcoholic extracts of leaves, stems, bark, pulp and seeds of. The extracts were prepared by homogenization of material in 50% ethanol. Minimum inhibitory concentration (MIC) was determined by the broth dilution method, and the bacterial strains tested wereand. Antibiotic-modifying activity was evaluated against the strains03 and08, using a subinhibitory concentration of extract. The antibiotics tested were: amikacin, gentamicin, ampicillin, potassium benzylpenicillin and oxacillin. The extracts did not show antimicrobial activity of clinical relevance, where the MIC was equal to or greater than 1024 μg/mL.showed 13 events, whileshowed only 4 events. Among these events, 14 involved synergistic activity, potentiating the effect of the antibiotics, and only 3 events demonstrated antagonistic activity toward ampicillin. Hydroalcoholic extracts are potential antimicrobial agents when combined with conventional drugs little utilized intreatment.

Study Type : In Vitro Study

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