Article Publish Status: FREE
Abstract Title:

Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils.

Abstract Source:

Neural Regen Res. 2016 Feb ;11(2):270-7. PMID: 27073380

Abstract Author(s):

Ki-Yeon Yoo, In Hye Kim, Jeong-Hwi Cho, Ji Hyeon Ahn, Joon Ha Park, Jae-Chul Lee, Hyun-Jin Tae, Dae Won Kim, Jong-Dai Kim, Seongkweon Hong, Moo-Ho Won, Il Jun Kang

Article Affiliation:

Ki-Yeon Yoo


In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne (CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive days followed by bilateral carotid artery occlusion to make a cerebral ischemia/reperfusion model. Then, we found that CIL extracts protected pyramidal neurons in the hippocampal CA1 region (CA1) from ischemic damage using neuronal nucleus immunohistochemistry and Fluoro-Jade B histofluorescence. Accordingly, interleukin-13 immunoreactivities in the CA1 pyramidal neurons of CIL-pretreated animals were maintained or increased after cerebral ischemia/reperfusion. These findings indicate that the pre-treatment of CIL can attenuate neuronal damage/death in the brain after cerebral ischemia/reperfusion via an anti-inflammatory approach.

Study Type : Animal Study

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