Abstract Title:

Premature graying of hair: Risk factors, co-morbid conditions, pharmacotherapy and reversal: A systematic review and meta-analysis.

Abstract Source:

Dermatol Ther. 2020 Jul 11:e13990. Epub 2020 Jul 11. PMID: 32654282

Abstract Author(s):

Saniya Mahendiratta, Phulen Sarma, Hardeep Kaur, Sukhmandeep Kaur, Harpinder Kaur, Seema Bansal, Davinder Prasad, Manisha Prajapat, Sujata Upadhay, Subodh Kumar, Harish Kumar, Rahul Singh, Ashutosh Singh, Abhishek Mishra, Ajay Prakash, Bikash Medhi

Article Affiliation:

Saniya Mahendiratta


Premature graying of hair (PGH) being a very common entity for which pharmacotherapy and reversibility are not properly addressed. Therefore, this systematic review was conducted to address these issues. For this relevant study were selected from various databases including PubMed, EMBASE, OVID, Web of science, Scopus and Google Scholar till January 20, 2019. Studies which reported risk factors, co-morbid conditions associated with PGH, its pharmacotherapy and reversal were included in the study. Although many risk factors are reported in literature, smoking, vitamin deficiency (B12, folic acid and B7), mineral deficiency (low serum calcium and serum ferritin) are found to be associated with PGH. Other important risk factors are family history of PGH, obesity, high B.P, lack of exercise, drugs, genetic syndromes, dyslipidemia, thyroid disorders, hyperuricemia and alteration in liver function. PGH is found to be an important marker of CAD, more so in case of smoker. Among different pharmacotherapeutic management options, low grade recommendation (2A) is given to calcium pantothenate, PABA, calcium pantothenate + PABA combination. Anu-tailam is the only herbal agent evaluated in clinical research settings. Finally treating the accompanying pathologies led to the reversal of the disease in many cases. This article is protected by copyright. All rights reserved.

Study Type : Meta Analysis, Review

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