Abstract Title:

Silicate nephrolithiasis after ingestion of supplements containing silica dioxide.

Abstract Source:

Am J Kidney Dis. 2009 Jul;54(1):127-30. Epub 2008 Dec 19. PMID: 19100669

Abstract Author(s):

Jennifer E Flythe, Jose F Rueda, Michael K Riscoe, Suzanne Watnick

Article Affiliation:

Division of Hospital and Specialty Medicine, Portland VA Medical Center, Portland, OR 97239, USA.


Silicate calculi are common in some mammals, such as dogs and sheep, but extremely rare in humans. We report a case of silicate calculi in a woman using oral over-the-counter Uncaria tomentosa, Digestive Advantage and FlexProtex supplements. All 3 contained the excipient silica dioxide. Stone analysis showed composition of 100% silicate. The nephrolithiasis promptly abated after discontinuation of the products containing silica, then returned when the patient restarted her supplements. This case emphasizes the importance of stone analysis when obvious causes of nephrolithiasis are unclear and highlights the concerns of using over-the-counter supplements without substantial oversight.

Study Type : Commentary
Additional Links
Problem Substances : Silicon Dioxide : CK(4) : AC(4)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.