Abstract Title:

Is vitamin D deficiency a risk factor for recurrent aphthous stomatitis? A systematic review and meta-analysis.

Abstract Source:

Oral Dis. 2019 Sep 6. Epub 2019 Sep 6. PMID: 31493304

Abstract Author(s):

Sadeq Ali Al-Maweri, Esam Halboub, Ghadah Al-Sufyani, Ahmed Yaseen Alqutaibi, Anas Shamala, Anas Alsalhani

Article Affiliation:

Sadeq Ali Al-Maweri


OBJECTIVES: A few studies have associated vitamin D deficiency with the occurrence of recurrent aphthous stomatitis (RAS). Hence, the aim of the present systematic review and meta-analysis is to explore such a potential association.

METHODS: A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted in June 2019.The inclusion criteria were: 1) observational studies that assessed the relationship between vitamin D and RAS, and 2) the outcome measures reported quantitative vitamin D levels. Studies without control groups, case series, case reports, experimental studies, letter to editors, reviews, were excluded. The random-effects model was conducted for meta-analyses using RevMan 5.3 software.

RESULTS: Five studies comprising 208 RAS patients and 241 healthy individuals were included. All studies except one reported significantly lower levels of vitamin D in RAS patients compared to the healthy individuals. The results of the pooled 5 studies revealed statistically significant lower levels of vitamin D in RAS patients (Mean Difference (MD) = -9.67 ng/mL, 95% CI= -15.68, -3.65; P˂ 0.002).

CONCLUSION: The present meta-analysis suggests a significant association between low vitamin D levels and RAS. Further well-designed studies with adequate sample sizes are required to elucidate the role of vitamin D in pathogenesis of RAS. This article is protected by copyright. All rights reserved.

Study Type : Meta Analysis, Review

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.