Article Publish Status: FREE
Abstract Title:

Botanicals as Modulators of Neuroplasticity: Focus on BDNF.

Abstract Source:

Neural Plast. 2017 ;2017:5965371. Epub 2017 Dec 31. PMID: 29464125

Abstract Author(s):

Enrico Sangiovanni, Paola Brivio, Mario Dell'Agli, Francesca Calabrese

Article Affiliation:

Enrico Sangiovanni


The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored. The present review considers the literature on the effects of botanicals on BDNF. Botanicals considered were(L.) Pennell,L.,L.,Maxim.,(L.) Kuntze (green tea),L.,L.,L. (olive oil),C.A. Meyer,L.,Bunge,L.,(L.) Dunal, and(L.) Britton. The effect of the active principles responsible for the efficacy of the extracts is reviewed and discussed as well. The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects. Further clinical studies are mandatory to confirm botanicals as preventive agents or as useful adjuvant to the pharmacological treatment.

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