Abstract Title:

Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome.

Abstract Source:

Phytother Res. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31746508

Abstract Author(s):

Javed Ahamad, Ibrahim Toufeeq, Mohammad Ahmed Khan, Muath Sh Mohammed Ameen, Esra T Anwer, Subha Uthirapathy, Showkat R Mir, Javed Ahmad

Article Affiliation:

Javed Ahamad


Olive (Olea europaea Linn., Fam. Oleaceae) is commonly known as Zaytoon in Mediterranean region. Its fruits and oil are essential components of Mediterranean diets. Olive tree is a prevalent plant species and one of the important cultivated crops of Mediterranean region. Oleuropein is a phenolic constituents of olive, which, along with its related compounds, has been indicated to be majorly responsible for its beneficial effects. Oleuropein is a secoiridoid type of phenolic compound and consists of three structural subunits: hydroxytyrosol, elenolic acid, and a glucose molecule. It is also reported to be the chemotaxonomic marker of olive. The oleuropein is reported to possess a number of biological activities including action against dyslipidemia, antiobesity, antidiabetic, antioxidant, antiatherogenic, antihypertensive, antiinflammatory, and hepatoprotective actions. The scientific evidence supports the role of oleuropein as a potential agent against metabolic syndrome. The present review discusses chemistry of oleuropein along with potential role of oleuropein with reference to pathophysiology of metabolic syndrome.

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