The effects of chrysin on serum corticosterone levels and brain oxidative injury induced by immobilization in rat.
Cardiovasc Hematol Disord Drug Targets. 2019 Jun 18. Epub 2019 Jun 18. PMID: 31237217
The current study was designed to investigate the effects of chrysin (CH) on serum corticosterone level. We also investigated depression-like behavior induced by chronic restraint stress in rats. The rats were kept in restrainers for 1 hour daily for 21 consecutive days. Then, the animals were daily injected with either vehicle or CH (10, 20, 30µg/kg) for 21 days. Our findings showed that the serum corticosterone levels significantly increased in rats submitted to the restraint stress versus non-stressed animals (p<0.001). The serum corticosterone levels were significantly lower in the stress-exposed rats administrated with CH than the stress-exposed non-treated rats (p<0.05). In addition, immobility time significantly increased in the rats submitted to restraint stress versus non-stressed group (p<0.001). Also, the number of crossing significantly decreased in the rats submitted to restraint stress versus non-stressed rats (p<0.001). The immobility time and the number of crossing were also reduced in the CH-administrated stressed rats (30 mg/kg) versus non-treated stressed group (p<0.001, p<0.05, respectively). CH also restored the levels of MDA and GSH and also the activities of antioxidant enzymes to the normal levels in stressed rats (p<0.05). The present study suggested that CH may be useful for the management of depressant-like effects induced by chronic stress via decreasing oxidative damage in the brain.