Abstract Title:

Preventive effect of apigenin against isoproterenol-induced apoptosis in cardiomyoblasts.

Abstract Source:

J Biochem Mol Toxicol. 2018 Nov ;32(11):e22213. Epub 2018 Aug 28. PMID: 30152906

Abstract Author(s):

Radhiga Thangaiyan, Beaulah Mary Robert, Sundaresan Arjunan, Kanimozhi Govindasamy, Rajendra Prasad Nagarajan

Article Affiliation:

Radhiga Thangaiyan


We investigated the effect of apigenin, a dietary flavonoid, on isoproterenol hydrochloride (ISO)-induced apoptotic signaling in cardiomyoblast H9C2 cells. The results showed that apigenin treatment (10 µM) prevented ISO (31.25 μM)-induced lipid peroxidative levels and antioxidants status in H9C2 cells. Furthermore, apigenin inhibited expression of inflammatory markers in ISO-treated cells. In addition, apigenin prevented ISO-induced DNA damage and apoptotic signaling through modulating theexpression of Bax, caspase-3, -8 and -9, cytochrome c, and Fas proteins in H9C2 cells. It is concluded that apigenin prevents ISO-induced antioxidants depletion, oxidative DNA damage, inflammatory, and apoptotic signaling in H9C2 cells. Thus, the present results demonstrated that apigenin has a cardioprotective effect on cardiomyoblasts cells.

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