Article Publish Status: FREE
Abstract Title:

Preventive Effect of Spontaneous Physical Activity on the Gut-Adipose Tissue in a Mouse Model That Mimics Crohn's Disease Susceptibility.

Abstract Source:

Cells. 2019 Jan 9 ;8(1). Epub 2019 Jan 9. PMID: 30634469

Abstract Author(s):

Florie Maillard, Emilie Vazeille, Pierre Sauvanet, Pascal Sirvent, Richard Bonnet, Lydie Combaret, Pierre Chausse, Caroline Chevarin, Yolanda Fernandez Otero, Geoffrey Delcros, Vivien Chavanelle, Nathalie Boisseau, Nicolas Barnich

Article Affiliation:

Florie Maillard


Crohn's disease is characterized by abnormal ileal colonization by adherent-invasive(AIEC) and expansion of mesenteric adipose tissue. This study assessed the preventive effect of spontaneous physical activity (PA) on the gut-adipose tissue in a mouse model that mimics Crohn's disease susceptibility. Thirty-five CEABAC10 male mice performed spontaneous PA (wheel group; n = 24) or not (controls; n = 11) for 12 weeks. At week 12, mice were orally challenged with the AIEC LF82 strain for 6 days. Body composition, glycaemic control, intestinal permeability, gut microbiota composition, and fecal short-chain fatty acids were assessed in both groups. Animals were fed a high fat/high sugar diet throughout the study. After exposure to AIEC, mesenteric adipose tissue weight was lower in the wheel group. Tight junction proteins expression increased with spontaneous PA, whereas systemic lipopolysaccharides were negatively correlated with the covered distance.anddecreased in controls, whereasandincreased in the wheel group. Fecal propionate and butyrate were also higher in the wheel group. In conclusion, spontaneous physical activity promotes healthy gut microbiota composition changes and increases short-chain fatty acids in CEABAC10 mice fed a Western diet and exposed to AIEC to mimic Crohn's disease.

Study Type : Animal Study
Additional Links
Therapeutic Actions : Exercise : CK(4855) : AC(736)
Anti Therapeutic Actions : Western Diet : CK(416) : AC(121)

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