Article Publish Status: FREE
Abstract Title:

The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells.

Abstract Source:

Cancer Cell. 2006 Apr ;9(4):301-12. PMID: 16616335

Abstract Author(s):

Arkaitz Carracedo, Mar Lorente, Ainara Egia, Cristina Blázquez, Stephane García, Valentin Giroux, Cedric Malicet, Raquel Villuendas, Meritxell Gironella, Luis González-Feria, Miguel Angel Piris, Juan L Iovanna, Manuel Guzmán, Guillermo Velasco

Article Affiliation:

Arkaitz Carracedo


One of the most exciting areas of current research in the cannabinoid field is the study of the potential application of these compounds as antitumoral drugs. Here, we describe the signaling pathway that mediates cannabinoid-induced apoptosis of tumor cells. By using a wide array of experimental approaches, we identify the stress-regulated protein p8 (also designated as candidate of metastasis 1) as an essential mediator of cannabinoid antitumoral action and show that p8 upregulation is dependent on de novo-synthesized ceramide. We also observe that p8 mediates its apoptotic effect via upregulation of the endoplasmic reticulum stress-related genes ATF-4, CHOP, and TRB3. Activation of this pathway may constitute a potential therapeutic strategy for inhibiting tumor growth.

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