Abstract Title:

Probiotics Efficacy on Oxidative Stress Values in Inflammatory Bowel Disease: A Randomized Double-Blinded Placebo-Controlled Pilot Study.

Abstract Source:

Endocr Metab Immune Disord Drug Targets. 2018 Dec 21. Epub 2018 Dec 21. PMID: 30574857

Abstract Author(s):

Andrea Ballini, Luigi Santacroce, Stefania Cantore, Lucrezia Bottalico, Gianna Dipalma, Skender Topi, Rajiv Saini, Danila De Vito, Francesco Inchingolo

Article Affiliation:

Andrea Ballini


BACKGROUND: Inflammatory bowel diseases (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), are described as a chronic inflammation of the small intestine and colon, caused by a dysregulated immune response to host intestinal microbiota in genetically susceptible subjects.

OBJECTIVE: The aim of this study was to compare probiotic therapy versus placebo in Oxidative Stress Values and clinical features in patients affected by IBD.

METHOD: Forty (40) patients previously diagnosed for IBD were recruited and randomized to receive probiotics (test group, n=20) or placebo (control group, n=20) administered for 90 days. Subjects in both the groups were assessed for overall oxidant ability (d-ROMs test) and for antioxidant response (BAP test): data were reported at baseline, after 1 and 3 months. Additional data from anamnesis and haematological investigations and were also reported during the study.

RESULTS: d-ROM assay clearly showed that the values observed in test group were significantly improved, leading to oxidative stress values not pathological. The test group showed increasing BAP values, thus confirming the overall improvements of patients 'health following administration of probiotics.

CONCLUSION: Oral administration of the specific probiotics demonstrated its efficacy and safety on patients affected by IBD.

Study Type : Human Study

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