Abstract Title:

Propolis extract has bioactivity on the wall and cell membrane of Candida albicans.

Abstract Source:

J Ethnopharmacol. 2020 Jun 28 ;256:112791. Epub 2020 Mar 28. PMID: 32234352

Abstract Author(s):

Jakeline L Corrêa, Flavia F Veiga, Isabele C Jarros, Maiara Ignacio Costa, Pamella F Castilho, Kelly Mari P de Oliveira, Hélen Cássia Rosseto, Marcos L Bruschi, Terezinha I E Svidzinski, Melyssa Negri

Article Affiliation:

Jakeline L Corrêa


ETHNOPHARMACOLOGICAL RELEVANCE: The use of natural products such as propolis extract (PE) is a promising alternative when topically administered to replace conventional antifungals, mostly due to its therapeutic applications, ease of access and low toxicity. However, despite being the subject of several mycology studies, they focus primarily on exploiting their antimicrobial activity, lacking information on the mechanisms of action of PE on Candida spp., characterizing its antifungal potential.

AIM OF THE STUDY: To elucidate the bioactivity of PE on the cellular structure of Candida albicans.

MATERIALS AND METHODS: A total of seven C. albicans clinical isolates plus a reference strain of C. albicans ATCC 90028 were used in this study. The PE was characterized and its effect on C. albicans was determined by susceptibility and growth kinetics assays; interference on C. albicans germination and filamentation; evaluation of the integrity of the C. albicans cell wall and membrane, as well as its mutagenic potential.

RESULTS: The PE presented strong inhibitory activity, which showed its greatest antifungal activity at 12 h with dose and time dependent fungistatic characteristics, effectively inhibiting and interfering on C. albicans filamentation. In addition, PE caused membrane and cell wall damage with intracellular content extravasation. Moreover, PE was not mutagenic.

CONCLUSIONS: The bioactivity of PE is mainly related to the loss of integrity membrane as well as the integrity of the cell wall and consequent increase in permeability, without mutagenic effects.

Study Type : In Vitro Study

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