Abstract Title:

Evaluation of the protective effects of Chinese herbs against biomolecule damage induced by peroxynitrite.

Abstract Source:

J Am Soc Hypertens. 2009 Mar-Apr;3(2):105-12. Epub 2009 Feb 20. PMID: 20622443

Abstract Author(s):

Yunjing Luo, Jinglin Pan, Yanshu Pan, Zhiguo Han, Rugang Zhong

Article Affiliation:

College of Life Science and Bioengineering, Beijing University of Technology, China. [email protected]


This work evaluates the protective effects of Chinese herbs against ONOO(-)-induced biomolecule damage. Thirty-two Chinese traditional herbs were preliminarily screened for their ONOO(-)-scavenging activity by the fluorometric method. The potency of scavenging activity was in the following order: Apis cerana Fabricius (Propolis)>Rosmarinus officinalis L (Rosemary)>Pseudolarix amabilis (Nelson) Rehd. (Pine Bark PE)>Echinacea Moenck. (Echinacea); the remaining twenty-eight herbs performed unsatisfactorily for their scavenging activity. The four extracts with high ONOO(-) scavenging activity were selected for further characterization of their inhibiting effects on DNA single breaks, tyrosine nitration and LDL oxidation. A further study of the origin of this scavenging activity on the major active components showed cichoric acid and rosemary acid to both have strong ability to scavenge ONOO(-). These scavengers might be developed as therapeutic drugs for preventing ONOO(-)-involved diseases.

Study Type : In Vitro Study

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