Abstract Title:

Protective Effect of Caffeic Acid against Alzheimer's Disease Pathogenesis via Modulating Cerebral Insulin Signaling,β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats.

Abstract Source:

J Agric Food Chem. 2019 Jun 28. Epub 2019 Jun 28. PMID: 31203623

Abstract Author(s):

Wenchang Chang, Dawei Huang, Y Martin Lo, Qinqiao Tee, Poling Kuo, James Swibea Wu, Wenchung Huang, Szuchuan Shen

Article Affiliation:

Wenchang Chang


This study investigated the alleviative effect of caffeic acid (CA) on Alzheimer's disease (AD) pathogenesis and associated mechanisms in high-fat (HF) diet-induced hyperinsulinemic rats. The results of a Morris water maze indicated that, by administrating CA (30 mg/kg b.w./day) for 30 weeks, the memory and learning impairments in HF-induced hyperinsulinemic rats were significantly ameliorated. CA also enhanced superoxide dismutase and glutathione free radical scavenger activity in hyperinsulinemic rats. The Western blot data further confirmed that protein expressions of phosphorylated-glycogen synthase kinase 3β (GSK3β) were significantly increased, whereas the expression of phosphorylated-tau protein decreased in the hippocampus of rats administered with CA in comparison with the HF group. Moreover, the expression of amyloid precursor protein (APP) and β-site APP cleaving enzyme were attenuated, subsequently lowering the level of β-amyloid 1-42 (Aβ 1-42) in the hippocampus of CA-treated hyperinsulinemic rats. CA also significantly increased the expression of synaptic proteins in HF rats.

Study Type : Animal Study

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