n/a
Abstract Title:

Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats.

Abstract Source:

Hypertens Pregnancy. 2021 Dec 22:1-8. Epub 2021 Dec 22. PMID: 34933650

Abstract Author(s):

Ying Li, Yuanyuan Liu, Jinfeng Chen, Jian Hu

Article Affiliation:

Ying Li

Abstract:

OBJECTIVE: This article is aimed to investigate the function and underlying action mechanism of Fisetin in LPS-induced PE rats.

METHODS: LPS-induced PE-like rat model was established to explore the effects of Fisetin on PE in vivo.

RESULTS: Fisetin reduced hypertension, proteinuria, TNF-α, IL-6, IL-1β, MDA, and sFlt-1/PlGF ratio, but elevated the placental, fetal weight, GSH and SOD in PE rats. Moreover, Fisetin suppressed TLR4/NF-κB pathway, as well as promoting Nrf2/HO-1 pathway in placental tissues of PE rats.

CONCLUSIONS: Fisetin exerted protective role and modulated the activation of TLR4/NF-κB and Nrf2/HO-1 pathways in PE-like rat models.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.