Article Publish Status: FREE
Abstract Title:

Protective Effect of a Fucose-Rich Fucoidan Isolated fromagainst Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish.

Abstract Source:

Mar Drugs. 2020 Jun 15 ;18(6). Epub 2020 Jun 15. PMID: 32549256

Abstract Author(s):

Wanchun Su, Lei Wang, Xiaoting Fu, Liying Ni, Delin Duan, Jiachao Xu, Xin Gao

Article Affiliation:

Wanchun Su


A fucose-rich fucoidan was purified from brown seaweed, of which the UVB protective effect was investigated in vitro in keratinocytes of HaCaT cells and in vivo in zebrafish. The intracellular reactive oxygen species levels and the viability of UVB-irradiated HaCaT cells were determined. The results indicate that the purified fucoidan significantly reduced the intracellular reactive oxygen species levels and improved the viability of UVB-irradiated HaCaT cells. Furthermore, the purified fucoidan remarkably decreased the apoptosis by regulating the expressions of Bax/Bcl-xL and cleaved caspase-3 in UVB-irradiated HaCaT cells in a dose-dependent manner. In addition, the in vivo UV protective effect of the purified fucoidan was investigated using a zebrafish model. It significantly reduced the intracellular reactive oxygen species level, the cell death, the NO production, and the lipid peroxidation in UVB-irradiated zebrafish in a dose-dependent manner. These results suggest that purified fucoidan has a great potential to be developed as a natural anti-UVB agent applied in the cosmetic industry.

Study Type : Animal Study, Human In Vitro

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